Increased expression of cyclooxygenase-2 (COX-2) in radiation-induced small bowel injury in rats

Keskek M., Gocmen E., Kilic M., Gencturk S., Can B., Cengiz M., ...More

JOURNAL OF SURGICAL RESEARCH, vol.135, no.1, pp.76-84, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 135 Issue: 1
  • Publication Date: 2006
  • Doi Number: 10.1016/j.jss.2006.03.031
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.76-84
  • Hacettepe University Affiliated: Yes


Background. Radiation therapy is a widely used adjuvant therapy for various abdominal and pelvic cancers. On the other hand, it is not a benign treatment modality, as most radiation patients suffer from some kind of radiation enteritis. Currently available treatments are only palliative and no ideal compound has as yet been discovered. The aim of this study was to evaluate cyclooxygenase-2 (COX-2) expression, and to investigate the possible protective effect of the selective COX-2 inhibitor, Rofecoxib, in acute and late stages of radiation-induced intestinal injury in rats.