Toward a better definition of focal cortical dysplasia: An iterative histopathological and genetic agreement trial

Bluemcke I., Coras R., Busch R. M., Morita-Sherman M., Lal D., Prayson R., ...Daha Fazla

EPILEPSIA, cilt.62, sa.6, ss.1416-1428, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62 Sayı: 6
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1111/epi.16899
  • Dergi Adı: EPILEPSIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1416-1428
  • Anahtar Kelimeler: brain, classification, epilepsy, genes, neuropathology, seizure, TEMPORAL-LOBE EPILEPSY, SOMATIC POINT MUTATIONS, WHITE-MATTER, CONSENSUS CLASSIFICATION, BRAIN-TISSUE, TASK-FORCE, SURGERY, INTEROBSERVER, HETEROTOPIA, CHILDREN
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objective Focal cortical dysplasia (FCD) is a major cause of difficult-to-treat epilepsy in children and young adults, and the diagnosis is currently based on microscopic review of surgical brain tissue using the International League Against Epilepsy classification scheme of 2011. We developed an iterative histopathological agreement trial with genetic testing to identify areas of diagnostic challenges in this widely used classification scheme.