Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child.

Ogishi M., Yang R., Aytekin C., Langlais D., Bourgey M., Khan T., ...More

Nature medicine, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2021
  • Doi Number: 10.1038/s41591-021-01388-5
  • Title of Journal : Nature medicine


Dysregulated immune features in a patient with a homozygous loss-of-function mutation in PDCD1 suggest that IL-6, IL-23, STAT3 and ROR gamma T might be potential targets for treatment of PD-1 blockade-induced autoimmunity.