Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child

Ogishi M., Yang R., Aytekin C., Langlais D., Bourgey M., Khan T., ...Daha Fazla

NATURE MEDICINE, cilt.27, sa.9, ss.1646-1680, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 9
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1038/s41591-021-01388-5
  • Dergi Adı: NATURE MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Public Affairs Index, Veterinary Science Database, DIALNET
  • Sayfa Sayıları: ss.1646-1680
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Dysregulated immune features in a patient with a homozygous loss-of-function mutation in PDCD1 suggest that IL-6, IL-23, STAT3 and ROR gamma T might be potential targets for treatment of PD-1 blockade-induced autoimmunity.