PTEN expression in diffuse large B-cell lymphomas


Onder S., Barista I., Sungur A., Ruacan S., ÜNER A.

17th European and African Division Meeting of the International-Society-of-Haematology, Graz, Austria, 7 - 10 September 2003, pp.125-131 identifier

  • Publication Type: Conference Paper / Full Text
  • Volume:
  • City: Graz
  • Country: Austria
  • Page Numbers: pp.125-131

Abstract

Diffuse large B-cell lymphomas (DLBCL) constitute the largest subgroup of non-Hodgkin lymphomas (NHL) in adults. Although the etiology of NHL is not fully understood, different genetic abnormalities, involving particularly oncogenes, were shown as a mechanism of lymphomagenesis. Mutations of tumor suppressor genes, unlike oncogenes, have been relatively less studied in DLBCL. PTEN, a tumor suppressor gene located at 10q23, has been shown to be mutated or deleted in a variety of solid tumors. In this study, loss of PTEN expression was evaluated immunohistochemically in 102 patients with DLBCL. Partial or complete loss of PTEN was detected in about one-third of the cases, leading to the conclusion that it might contribute to the lymphomagenesis in some cases.