Dual inhibition of the epidermal growth factor and vascular endothelial growth factor phosphorylation for antivascular therapy of human prostate cancer in the prostate of nude mice


Yazici S. , Kim S., Busby J., He J., Thaker P., Yokoi K., ...Daha Fazla

PROSTATE, cilt.65, ss.203-215, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 65 Konu: 3
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1002/pros.20283
  • Dergi Adı: PROSTATE
  • Sayfa Sayıları: ss.203-215

Özet

BACKGROUND. Androgen-independent prostate cancer (PCa) may be susceptible to modulation of the tumor microenvironment. We determined whether a dual tyrosine kinase inhibitor (AEE788) of the epidermal growth factor receptor (EGF-R) and vascular endothelial growth factor receptor (VEGF-R) combined with chemotherapy can produce therapy of human PCa in nude mice.