Investigation of myorelaxant activity of 9-aryl-3,4,6,7-tetrahydroacridine-1,8-(2H,5H,9H,10H)-diones in isolated rabbit gastric fundus

Fincan G. S. O., GÜNDÜZ M. G., Vural I. M., ŞİMŞEK R., Sarioglu Y., Safak C.

MEDICINAL CHEMISTRY RESEARCH, cilt.21, sa.8, ss.1817-1824, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 8
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s00044-011-9698-x
  • Dergi Adı: MEDICINAL CHEMISTRY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1817-1824
  • Anahtar Kelimeler: Myorelaxant activity, Acridinedione, Pinacidil, ATP CHANNEL OPENERS, POTASSIUM CHANNELS, K+ CHANNELS, CALCIUM, PHARMACOLOGY, DERIVATIVES, SERIES
  • Hacettepe Üniversitesi Adresli: Evet

Özet

In this study, twelve compounds having 9-aryl-3,4,6,7-tetrahydroacridine-1,8-(2H,5H,9H,10H)-dione structure were synthesized by reaction of 5-methyl-1,3-cyclohexanedione, the appropriate aromatic aldehydes, and ammonium acetate in methanol. The structures of the compounds were elucidated by infrared, H-1- and C-13-nuclear magnetic resonance spectroscopy (-NMR), mass spectroscopy, and elemental analysis. The maximum relaxant effects (E (max)) and pD2 values of the compounds 3a-l and pinacidil were tested on isolated strips of rabbit gastric fundus smooth muscle.