Investigation of myorelaxant activity of 9-aryl-3,4,6,7-tetrahydroacridine-1,8-(2H,5H,9H,10H)-diones in isolated rabbit gastric fundus


Fincan G. S. O. , GÜNDÜZ M. G. , Vural I. M. , ŞİMŞEK R., Sarioglu Y., Safak C.

MEDICINAL CHEMISTRY RESEARCH, vol.21, no.8, pp.1817-1824, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 8
  • Publication Date: 2012
  • Doi Number: 10.1007/s00044-011-9698-x
  • Journal Name: MEDICINAL CHEMISTRY RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1817-1824
  • Keywords: Myorelaxant activity, Acridinedione, Pinacidil, ATP CHANNEL OPENERS, POTASSIUM CHANNELS, K+ CHANNELS, CALCIUM, PHARMACOLOGY, DERIVATIVES, SERIES
  • Hacettepe University Affiliated: Yes

Abstract

In this study, twelve compounds having 9-aryl-3,4,6,7-tetrahydroacridine-1,8-(2H,5H,9H,10H)-dione structure were synthesized by reaction of 5-methyl-1,3-cyclohexanedione, the appropriate aromatic aldehydes, and ammonium acetate in methanol. The structures of the compounds were elucidated by infrared, H-1- and C-13-nuclear magnetic resonance spectroscopy (-NMR), mass spectroscopy, and elemental analysis. The maximum relaxant effects (E (max)) and pD2 values of the compounds 3a-l and pinacidil were tested on isolated strips of rabbit gastric fundus smooth muscle.