Protective effects of curcumin against oxidative stress parameters and DNA damage in the livers and kidneys of rats with biliary obstruction

Tokac M., Taner G., Aydin S., Ozkardes A. B., Dundar H. Z., Taslipinar M. Y., ...Daha Fazla

FOOD AND CHEMICAL TOXICOLOGY, cilt.61, ss.28-35, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.fct.2013.01.015
  • Dergi Adı: FOOD AND CHEMICAL TOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.28-35
  • Anahtar Kelimeler: Curcumin, Bile duct ligation, Cholestasis, Liver functions, Oxidative stress, DNA damage, BILE-DUCT LIGATION, KAPPA-B ACTIVATION, HISTOLOGICAL ALTERATIONS, NITRIC-OXIDE, ANTIOXIDANT, BILIRUBIN, DEXAMETHASONE, NEUROTOXICITY, MITOCHONDRIA, MODULATION
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Curcumin, a most active antioxidant compound, has been suggested to have potential beneficial effects against most metabolic and psychological disorders, including cholestasis. In the present study, the effects of curcumin against oxidative stress and DNA damage induced by bile duct ligation (BDL) in Wistar albino rats for 14 days were investigated. The rats were divided into three following groups: Sham group, the BDL group and the BDL + curcumin group. A daily dose of 50 mg/kg curcumin was given to the BDL + curcumin group intragastrically for 14 days. The biomarkers of hepatocellular damage were decreased in the BDL + curcumin group compared to the BDL group, indicating that curcumin recovered the liver functions. DNA damage as assessed by the alkaline comet assay was also found to be low in the BDL + curcumin group. Curcumin significantly reduced malondialdehyde and nitric oxide levels, and enchanced reduced glutathione levels and catalase, superoxide dismutase, and glutathione S-transferase enzymes activities in the livers and kidneys of BDL group. Curcumin treatment in BDL group was found to decrease tumor necrosis factor-alpha levels in the livers of rats. These results suggest that curcumin might have protective effects on the cholestasis-induced injuries in the liver and kidney tissues of rats. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.