INVESTIGATION OF DNA BINDING AND CLEAVAGE ACTIVITIES OF BORON COMPLEXES IN THE PRESENCE OF HYDROGEN PEROXIDE
STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA, vol.59, no.3, pp.109-118, 2014 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 59 Issue: 3
- Publication Date: 2014
- Journal Name: STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.109-118
- Hacettepe University Affiliated: Yes
Abstract
Magnesium [di(hydroxy)mono(citratoborate)]dihydrate (Mg[B(Cit)(OH)(2)](2)center dot 2H2O), Lithium [di(hydroxy)mono(citratoborate)]hydrate Li[B(Cit)(OH)(2)]center dot H2O, Sodium [di(hydroxy)mono(salicylato) borate)hydrate Na[B(Sal)(OH)(2)]center dot H2O and Magnesium[bis(salicylatoborate)]decahydrate Mg[B(Sal)(2)](2)center dot 10H(2)O) complexes have been synthesized and characterized. The cattle genomic DNA (CG-DNA) interaction of the complexes was studied by spectroscopic methods, viscosity, and electrophoresis measurements. The complexes partially intercalated to CG-DNA. Furthermore, DNA cleavage activity of these complexes was also investigated using agarose gel electrophoresis and the complexes show moderate ability of cleavage to the DNA.