INVESTIGATION OF DNA BINDING AND CLEAVAGE ACTIVITIES OF BORON COMPLEXES IN THE PRESENCE OF HYDROGEN PEROXIDE

Devrim A. K., Arslantas A., Sudagidan M., KÖSE D. A., KARAN B.

STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA, cilt.59, sa.3, ss.109-118, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 3
  • Basım Tarihi: 2014
  • Dergi Adı: STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.109-118
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Magnesium [di(hydroxy)mono(citratoborate)]dihydrate (Mg[B(Cit)(OH)(2)](2)center dot 2H2O), Lithium [di(hydroxy)mono(citratoborate)]hydrate Li[B(Cit)(OH)(2)]center dot H2O, Sodium [di(hydroxy)mono(salicylato) borate)hydrate Na[B(Sal)(OH)(2)]center dot H2O and Magnesium[bis(salicylatoborate)]decahydrate Mg[B(Sal)(2)](2)center dot 10H(2)O) complexes have been synthesized and characterized. The cattle genomic DNA (CG-DNA) interaction of the complexes was studied by spectroscopic methods, viscosity, and electrophoresis measurements. The complexes partially intercalated to CG-DNA. Furthermore, DNA cleavage activity of these complexes was also investigated using agarose gel electrophoresis and the complexes show moderate ability of cleavage to the DNA.