Invasive group A streptococcal infection with pancarditis caused by a new emm-type 12 allele of Streptococcus pyogenes

Özkaya G., Shorbagi A., Ülger Z., Saglam A., AYBAR M., Şardan Y. Ç., ...More

Journal of Infection, vol.53, no.1, 2006 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 1
  • Publication Date: 2006
  • Doi Number: 10.1016/j.jinf.2005.10.006
  • Journal Name: Journal of Infection
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: emm-Type 12 allele, Invasive infection, Pancarditis, Streptococcus pyogenes
  • Hacettepe University Affiliated: Yes

Abstract

Throughout the 1980s, a progressive increase in the incidence of Streptococcus pyogenes-related invasive infections has occurred. It has been suggested that a host-related immunogenetic background, as well as bacterial virulence factors may play an important role in the outcome of streptococcal infections. Here, we present the first case of pancarditis in the literature caused by direct bacterial invasion due to a new emm-type 12 allele of S. pyogenes in an immunocompetent patient. The pathogenesis of this invasive infection, as well as predictors of poor prognosis are discussed. © 2005 The British Infection Society.