Invasive group A streptococcal infection with pancarditis caused by a new emm-type 12 allele of Streptococcus pyogenes

Özkaya, Gülşen; Shorbagi, Ali; Ülger, Zekeriya; Saglam, Arzu; AYBAR, MELDA; Şardan, Yeşim; UZUN, ÖMRÜM

doi:10.1016/j.jinf.2005.10.006

Invasive group A streptococcal infection with pancarditis caused by a new emm-type 12 allele of Streptococcus pyogenes

Özkaya G., Shorbagi A., Ülger Z., Saglam A., AYBAR M., Şardan Y. Ç., ...Daha Fazla

Journal of Infection, cilt.53, sa.1, 2006 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 53 Sayı: 1
Basım Tarihi: 2006
Doi Numarası: 10.1016/j.jinf.2005.10.006
Dergi Adı: Journal of Infection
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Anahtar Kelimeler: emm-Type 12 allele, Invasive infection, Pancarditis, Streptococcus pyogenes
Hacettepe Üniversitesi Adresli: Evet

Özet

Throughout the 1980s, a progressive increase in the incidence of Streptococcus pyogenes-related invasive infections has occurred. It has been suggested that a host-related immunogenetic background, as well as bacterial virulence factors may play an important role in the outcome of streptococcal infections. Here, we present the first case of pancarditis in the literature caused by direct bacterial invasion due to a new emm-type 12 allele of S. pyogenes in an immunocompetent patient. The pathogenesis of this invasive infection, as well as predictors of poor prognosis are discussed. © 2005 The British Infection Society.