Angiotensin-converting enzyme genotype predicts valve damage in acute rheumatic fever

Atalar, E; Tokgozoglu, SL; Alikasifoglu, M; Ovunc, K; Aksoyek, S; Kes, S; Tuncbilek, ERGÜL

Angiotensin-converting enzyme genotype predicts valve damage in acute rheumatic fever

Atalar E., Tokgozoglu S., Alikasifoglu M., Ovunc K., Aksoyek S., Kes S., ...Daha Fazla

JOURNAL OF HEART VALVE DISEASE, cilt.12, sa.1, ss.7-10, 2003 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 12 Sayı: 1
Basım Tarihi: 2003
Dergi Adı: JOURNAL OF HEART VALVE DISEASE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.7-10
Hacettepe Üniversitesi Adresli: Evet

Özet

Background and aim of the study: The genetic basis for host susceptibility to subsequent valve damage and scarring is not well defined in patients with a history of acute rheumatic fever (ARF). A high angiotensin-converting enzyme (ACE) activity has been demonstrated in valve tissue; hence, the study aim was to determine whether the ACE-DD genotype was a predisposing factor to heart valve damage after ARF attack.