Angiotensin-converting enzyme genotype predicts valve damage in acute rheumatic fever


Atalar E., Tokgozoglu S., Alikasifoglu M., Ovunc K., Aksoyek S., Kes S., ...More

JOURNAL OF HEART VALVE DISEASE, vol.12, no.1, pp.7-10, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 1
  • Publication Date: 2003
  • Journal Name: JOURNAL OF HEART VALVE DISEASE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.7-10
  • Hacettepe University Affiliated: Yes

Abstract

Background and aim of the study: The genetic basis for host susceptibility to subsequent valve damage and scarring is not well defined in patients with a history of acute rheumatic fever (ARF). A high angiotensin-converting enzyme (ACE) activity has been demonstrated in valve tissue; hence, the study aim was to determine whether the ACE-DD genotype was a predisposing factor to heart valve damage after ARF attack.