Efficacy of tenofovir in adefovir-experienced patients compared with treatment-naive patients with chronic hepatitis B

KESKİN O. , Ormeci A. C. , BARAN B., KABAÇAM G., TÜZÜN A. E. , KARATAYLI E., ...More

ANTIVIRAL THERAPY, vol.19, no.6, pp.543-550, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 6
  • Publication Date: 2014
  • Doi Number: 10.3851/imp2732
  • Title of Journal : ANTIVIRAL THERAPY
  • Page Numbers: pp.543-550


Background: Tenofovir (TDF) has similar antiviral efficacy in both treatment-naive and lamivudine-resistant chronic hepatitis B (CHB) patients. Data on TDF use in patients with adefovir (ADV) resistance is inconsistent. The aim of our study was to assess antiviral efficacy of TDF against nucleoside analogue-naive (NN) and ADV-resistant (ADV-R) CHB and suboptimal responders to ADV (ADV-S).