Interferon alfa-2b, colchicine, and benzathine penicillin versus colchicine and benzathine penicillin in Behcet's disease: a randomised trial

Demiroglu H., Ozcebe O., Barista I., Dundar S., Eldem B.

LANCET, vol.355, no.9204, pp.605-609, 2000 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 355 Issue: 9204
  • Publication Date: 2000
  • Doi Number: 10.1016/s0140-6736(99)05131-4
  • Journal Name: LANCET
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.605-609
  • Hacettepe University Affiliated: Yes


Background Sight-threatening eye involvement is a serious complication of Behcet's disease. Extraocular complications such as arthritis, vascular occlusive disorders, mucocutaneous lesions, and central-nervous-system disease may lead to morbidity and even death. We designed a prospective study in newly diagnosed patients without previous eye disease to assess whether prevention of eye involvement and extraocular manifestations, and preservation of visual acuity are possible with combination treatments with and without interferon alfa-2b.