Plasma and gingival crevicular fluid phenytoin concentrations as risk factors for gingival overgrowth

Guncu G. N., Caglayan F., Dincel A., Bozkurt A., Saygi S., Karabulut E.

JOURNAL OF PERIODONTOLOGY, vol.77, no.12, pp.2005-2010, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 77 Issue: 12
  • Publication Date: 2006
  • Doi Number: 10.1902/jop.2006.060103
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2005-2010
  • Hacettepe University Affiliated: Yes


Background: Gingival enlargement is one of the side effects associated with the administration of phenytoin. The mechanism by which phenytoin induces gingival enlargement is not well understood. This study was conducted to investigate the relationship between plasma and gingival crevicular fluid (GCF) phenytoin concentrations and the degree of gingival overgrowth in patients with similar gingival and plaque indices and also to determine the risk factors for gingival enlargement.