Radiosterilization of sulfonamides: I: determination of the effects of gamma irradiation on solid sulfonamides
RADIATION PHYSICS AND CHEMISTRY, cilt.69, sa.6, ss.511-520, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 69 Sayı: 6
- Basım Tarihi: 2004
- Doi Numarası: 10.1016/j.radphyschem.2003.09.005
- Dergi Adı: RADIATION PHYSICS AND CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.511-520
- Hacettepe Üniversitesi Adresli: Evet
Özet
Three antibiotics sulfafurazole (SFZ), sulfamethoxazole (SMZ) and sulfacetamide sodium (SSA-Na) belonging to sulfonamides were irradiated and changes in physico-chemical properties, pH, melting points, UV, IR, NMR, TLC, GC-MS, ESR characteristics, antimicrobial activities of active components were studied at normal and accelerated stability test conditions. Two radiolytic intermediates for both SFZ and SMZ and four radiolytic intermediates for SSA-Na were found in the irradiated solid samples after the GC-MS analysis. The results obtained under normal and accelerated stability test conditions were observed to be consistent with the unirradiated values. (C) 2003 Elsevier Ltd. All rights reserved.