Radiosterilization of sulfonamides: I: determination of the effects of gamma irradiation on solid sulfonamides

Mercanoglu G., Ozer A. Y., Colak S., Korkmaz M., Ozalp M. A., Ekizoglu M., ...More

RADIATION PHYSICS AND CHEMISTRY, vol.69, no.6, pp.511-520, 2004 (SCI-Expanded) identifier identifier


Three antibiotics sulfafurazole (SFZ), sulfamethoxazole (SMZ) and sulfacetamide sodium (SSA-Na) belonging to sulfonamides were irradiated and changes in physico-chemical properties, pH, melting points, UV, IR, NMR, TLC, GC-MS, ESR characteristics, antimicrobial activities of active components were studied at normal and accelerated stability test conditions. Two radiolytic intermediates for both SFZ and SMZ and four radiolytic intermediates for SSA-Na were found in the irradiated solid samples after the GC-MS analysis. The results obtained under normal and accelerated stability test conditions were observed to be consistent with the unirradiated values. (C) 2003 Elsevier Ltd. All rights reserved.