Surface-modified bacterial nanofibrillar PHB scaffolds for bladder tissue repair
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, vol.44, no.1, pp.74-82, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 44 Issue: 1
- Publication Date: 2016
- Doi Number: 10.3109/21691401.2014.913053
- Journal Name: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.74-82
- Open Archive Collection: AVESIS Open Access Collection
- Hacettepe University Affiliated: Yes
Abstract
The aim of the study is in vitro investigation of the feasibility of surface-modified bacterial nanofibrous poly [(R)-3-hydroxybutyrate] (PHB) graft for bladder reconstruction. In this study, the surface of electrospun bacterial PHB was modified with PEG- or EDA via radio frequency glow discharge method. After plasma modification, contact angle of EDA-modified PHB scaffolds decreased from 110 +/- 1.50 to 23 +/- 0.5 degree. Interestingly, less calcium oxalate stone deposition was observed on modified PHB scaffolds compared to that of non-modified group. Results of this study show that surface-modified scaffolds not only inhibited calcium oxalate growth but also enhanced the uroepithelial cell viability and proliferation.