Elevated serum angiotensin converting enzyme levels as a reflection of bone marrow renin-angiotensin system activation in multiple myeloma

Albayrak, Murat; Celebi, Harika; Albayrak, Aynur; Sayilir, Abdurrahim; YEŞİL, YUSUF; Balcik, Ozlem; Yokus, Osman; Celik, Tugrul

doi:10.1177/1470320312437070

Elevated serum angiotensin converting enzyme levels as a reflection of bone marrow renin-angiotensin system activation in multiple myeloma

Albayrak M., Celebi H., Albayrak A., Sayilir A., YEŞİL Y., Balcik O. S., ...Daha Fazla

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, cilt.13, sa.2, ss.259-264, 2012 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 13 Sayı: 2
Basım Tarihi: 2012
Doi Numarası: 10.1177/1470320312437070
Dergi Adı: JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.259-264
Hacettepe Üniversitesi Adresli: Evet

Özet

Introduction: Angiotensin converting enzyme (ACE) is a circulating enzyme that participates in the body's renin-angiotensin system (RAS) and is localized on the endothelial cell surface in the lung and other vascular beds. It catalyses the conversion of decapeptide angiotensin I to octapeptide angiotensin II. In the present study, we aimed to analyse the possible relationship between the levels of ACE in the context of RAS in multiple myeloma (MM) pathogenesis.