Expression of water channel aquaporin-4 during experimental syringomyelia: Laboratory investigation

Aghayev K., Bal E., Rahimli T., Mut M., Balci S., Vrionis F., ...More

Journal of Neurosurgery: Spine, vol.15, no.4, pp.428-432, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.3171/2011.5.spine10303
  • Journal Name: Journal of Neurosurgery: Spine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.428-432
  • Hacettepe University Affiliated: Yes


Object. Aquaporins (aqp) are protein channels providing water transport across cell membranes. The main member of this family expressed in the CNS is aqp-4. The pattern and amount of expression of this channel suggest a dominant role in bulk water movement into the nervous tissue. It has also been shown to play a role in several water balance disorders in the CNS. In this study, the authors investigated the possible role of aqp-4 in syringomyelia.