Purpose: To compare perceived health related quality of life (HRQoL) of two different patient groups of neurological diseases. Materials and methods: In this study 54 (28/26 male/female) ambulatory patients who had participated in an outpatient treatment program in a neurological rehabilitation unit and having similar demographic, physical and functional characteristics were evaluated. The patients were divided into two groups depending on their congenital (N=27) and acquired (N=27) neurological diseases. Information related to backgrounds, their pain complaints, functional levels ( Functional Independence Measurement), mobility (Rivermead Mobility Index) and perceived HRQoL ( Nottingham Health Profile) levels were recorded from their files retrospectively. Results: There was no significant difference between the RMI and FIM scores (p>0.05). The energy level, emotional reactions, physical activity parameters and the total scores of the NHP in the group with congenital neurological disease were significantly higher than the other group (p<0.05). There was no significant difference between the two groups regarding pain, sleep and social isolation parameters of the NHP (p>0.05). Discussion: Perceived HRQoL of the patients with the congenital neurological disorders were lower than the the other patients with acquired neurological diseases. Due to the nature of the neurological disease, HRQoL which can be affected in various dimensions, should be observed closely with regard to the objectives of the neurological rehabilitation programs.