PKC stimulation increases expression of cholinesterases in R28 cell line


Creative Commons License

BODUR E. , LAYER P. G.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.39, ss.201-205, 2014 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 39 Konu: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5505/tjb.2014.38981
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Sayfa Sayıları: ss.201-205

Özet

Objective: Previously we have shown a counter-regulation between cholinesterases (ChEs) through both anti-sense Butyrylcholinesterase (BChE) transfection and knock-down by siRNAs in R28 cells. In course of this counter-regulation, the status of the cell growth- and differentiation-related signaling pathways PKC and ERK were also changed. Down-regulation of BChE led to an increased PKC-alpha expression. Here, we demonstrate that this interaction between ChEs and PKC is reciprocal.