PKC stimulation increases expression of cholinesterases in R28 cell line
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.39, sa.2, ss.201-205, 2014 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 39 Sayı: 2
- Basım Tarihi: 2014
- Doi Numarası: 10.5505/tjb.2014.38981
- Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.201-205
- Hacettepe Üniversitesi Adresli: Evet
Özet
Objective: Previously we have shown a counter-regulation between cholinesterases (ChEs) through both anti-sense Butyrylcholinesterase (BChE) transfection and knock-down by siRNAs in R28 cells. In course of this counter-regulation, the status of the cell growth- and differentiation-related signaling pathways PKC and ERK were also changed. Down-regulation of BChE led to an increased PKC-alpha expression. Here, we demonstrate that this interaction between ChEs and PKC is reciprocal.