Improved oxidative status in major abdominal surgery patients after N-acetyl cystein supplementation


Kuyumcu A., Akyol A., Buyuktuncer Z., OZMEN M. M. , BESLER H. T.

NUTRITION JOURNAL, vol.14, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14
  • Publication Date: 2015
  • Doi Number: 10.1186/1475-2891-14-4
  • Journal Name: NUTRITION JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Major abdominal surgery, N-acetyl cystein, Plasma amino acids, Oxidant parameters, TOTAL PARENTERAL-NUTRITION, RANDOMIZED CONTROLLED-TRIAL, LENGTH-OF-STAY, GASTROINTESTINAL CANCER, ATRIAL-FIBRILLATION, AMINO-ACIDS, ACETYLCYSTEINE SUPPLEMENTATION, ANTIOXIDANT DEFENSES, REPERFUSION INJURY, HUMAN ERYTHROCYTES
  • Hacettepe University Affiliated: Yes

Abstract

Background: Increased levels of reactive oxygen species during and after surgery may affect inflammatory response, post-operative adhesion molecule formation, and hemodynamic stability. The glutathione redox cycle is an important regulator in oxidative stress and its reduced forms scavenge free radicals. N-acetyl cysteine, a precursor of reduced glutathione, is considered as a potentially therapeutic wide spectrum agent in clinical practice. We therefore examined whether N-acetyl cysteine improves some biochemical parameters in cancer patients undergoing major abdominal surgery.