Evaluation of adrenocortical function in 3-7 aged asthmatic children treated with moderate doses of fluticasone propionate: reliability of dehydroepiandrosterone sulphate (dhea-s) as a screening test

Sahiner Ü. M., Cetinkaya S., Ozmen S., Arslan Z.

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, cilt.39, sa.3, ss.154-158, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.aller.2010.06.005
  • Dergi Adı: ALLERGOLOGIA ET IMMUNOPATHOLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.154-158
  • Anahtar Kelimeler: Asthma, children, dehydroepiandrosterone sulphate, adrenal axis supression, fluticasone propionate, SYMPTOMATIC ADRENAL INSUFFICIENCY, INHALED CORTICOSTEROIDS, SUPPRESSION, CORTISOL, EFFICACY, GROWTH, ADULTS, ADOLESCENTS, SECRETION, INDICATOR
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Inhaled corticosteroids (ICS) are the first-line therapy in the treatment of persistent asthma. At medium to high doses and prolonged usage, ICS can supresss the hypothalamic-pituitary-adrenal axis. Dehydroepiandrosterone sulphate (DHEA-S) is a corticotropin-dependent adrenal androgen precursor that is supressible in patients treated with ICS. Objectives: To evaluate the adrenal axis in asthmatic children treated with moderate doses of fluticasone propionate and to evaluate the DHEA-S as a possible marker for adrenal axis in preadrenarchal children.