Evaluation of adrenocortical function in 3-7 aged asthmatic children treated with moderate doses of fluticasone propionate: reliability of dehydroepiandrosterone sulphate (dhea-s) as a screening test


Sahiner Ü. M., Cetinkaya S., Ozmen S., Arslan Z.

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, vol.39, no.3, pp.154-158, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.1016/j.aller.2010.06.005
  • Journal Name: ALLERGOLOGIA ET IMMUNOPATHOLOGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.154-158
  • Keywords: Asthma, children, dehydroepiandrosterone sulphate, adrenal axis supression, fluticasone propionate, SYMPTOMATIC ADRENAL INSUFFICIENCY, INHALED CORTICOSTEROIDS, SUPPRESSION, CORTISOL, EFFICACY, GROWTH, ADULTS, ADOLESCENTS, SECRETION, INDICATOR
  • Hacettepe University Affiliated: Yes

Abstract

Background: Inhaled corticosteroids (ICS) are the first-line therapy in the treatment of persistent asthma. At medium to high doses and prolonged usage, ICS can supresss the hypothalamic-pituitary-adrenal axis. Dehydroepiandrosterone sulphate (DHEA-S) is a corticotropin-dependent adrenal androgen precursor that is supressible in patients treated with ICS. Objectives: To evaluate the adrenal axis in asthmatic children treated with moderate doses of fluticasone propionate and to evaluate the DHEA-S as a possible marker for adrenal axis in preadrenarchal children.