TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, vol.28, no.6, pp.874-879, 2008 (SCI-Expanded)
Objective: Identification of the histological type of lung cancer plays an important role in prognosis and management of therapy. In this study, we aimed to compare fiberoptic bronchoscopic methods and to determine which one was more accurate in the diagnosis of lung cancer. Material and Methods: Four hundred and sixty patients with lung cancer were included in our study. Fiberoptic bronchoscopic methods were investigated retrospectively in lung cancer patients who had undergone fiberoptic bronchoscopy. Results: The diagnostic value of fiberoptic bronchoscopic methods, which were endobronchial biopsy, bronchial lavage, brush biopsy, and transbronchial needle aspiration biopsy, were 74.4%, 26.3%, 46.8%, and 56.4%, respectively. In addition, we compared the combination of these methods. The diagnostic value of the combinations of endobronchial biopsy and bronchial lavage; endobronchial biopsy and transbronchial needle aspiration biopsy; and endobronchial biopsy and brush biopsy were 79.1%, 85.5%, and 79.4%, respectively. The diagnostic value of three-method-combinations of endobronchial biopsy, bronchial lavage and brush biopsy; and endobronchial biopsy, bronchial lavage and transbronchial needle aspiration biopsy were 81.8%, and 86.5%, respectively. When the lesions were assessed according to fiberoptic bronchoscopic appearance, the diagnostic value of the transbronchial needle aspiration biopsy was higher compared to endobronchial biopsy and brush biopsy in the submucosal lesions. Conclusion: Although endobronchial biopsy alone was a successful method, the value of combination of endobronchial biopsy, bronchial lavage, and transbronchial needle aspiration biopsy yielded the most accurate diagnostic value. The combination of fiberoptic bronchoscopic methods increases the diagnostic accuracy in lung cancer.