Effects of cellular energy homeostasis modulation through AMPK on regulation of protein translation and response to hypoxia

GÜNAYDIN G., Gedik M. E.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.44, no.5, pp.611-620, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 5
  • Publication Date: 2019
  • Doi Number: 10.1515/tjb-2018-0338
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.611-620
  • Keywords: A769662, AMPK, Breast cancer, Dorsomorphin, eEF2K, Hepatocellular cancer, HIF-1 alpha, TUMOR-CELLS, KINASE, CANCER, TARGET, GROWTH
  • Hacettepe University Affiliated: Yes

Abstract

Objective: AMP-activated-protein-kinase (AMPK) regulates cellular energy-homeostasis. Eukaryotic-elongationfactor-2-kinase (eEF2K) plays important roles in regulating protein-synthesis, functions similarly to AMPK to protect cancer-cells from metabolic stress. Tumor-hypoxia induces angiogenesis with activation of hypoxia-inducible-factor-1-alpha (HIF-1 alpha). AMPK might be implicated both in regulation of protein-translation and response-to-hypoxia. We aimed to investigate the effects of AMPK modulation on regulation of protein translation and response-to-hypoxia by evaluating eEF2K and HIF-1 alpha proteins in breast and hepatocellular cancers.