Impact of lymph node ratio in patients with stage IIIC endometrial carcinoma treated with postoperative radiotherapy

Onal C., Sari S., Yavas G., Guler O. C., Yigit E., Oymak E., ...Daha Fazla

FUTURE ONCOLOGY, cilt.17, ss.3321-3330, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2217/fon-2020-1308
  • Dergi Adı: FUTURE ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.3321-3330
  • Anahtar Kelimeler: endometrial cancer, lymph node ratio, radiotherapy, surgery, survival, CANCER-PATIENTS, PELVIC LYMPHADENECTOMY, CHEMOTHERAPY, INVOLVEMENT, RADIATION, RESECTION, SURVIVAL, THERAPY
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Aim: To evaluate the prognostic value of the lymph node ratio (LNR) and other clinicopathological factors in patients with stage IIIC endometrial cancer. Methods: Factors affecting overall survival (OS) and progression-free survival (PFS) were assessed in 397 patients with stage IIIC endometrial cancer treated with postoperative radiotherapy. Patients undergoing the removal of at least ten lymph nodes were included in the study. Results: The 5-year OS and PFS rates were 58% and 52%, respectively, with a median follow-up time of 35.7 months. The LNR cutoff value was 9.6%. In the multivariate analysis, advanced age (>= 60 years), grade III tumor, presence of cervical stromal invasion, higher LNR and lack of adjuvant chemotherapy were independent predictors for worse OS and PFS. Conclusion: The LNR is an independent predictor for OS and PFS in patients with stage IIIC endometrial cancer treated with postoperative radiotherapy.