New avenues in childhood vasculitis

ERCAN EMREOL H., Yildirim-Toruner C., Jelusic M., Twilt M., ÖZEN S.

PEDIATRIC RHEUMATOLOGY, vol.23, no.1, 2025 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Review
  • Volume: 23 Issue: 1
  • Publication Date: 2025
  • Doi Number: 10.1186/s12969-025-01149-5
  • Journal Name: PEDIATRIC RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
  • Hacettepe University Affiliated: Yes

Abstract

Childhood vasculitis encompasses a group of rare and heterogeneous diseases with systemic inflammation affecting various vessel sizes. This comprehensive review highlights recent advances in the pathogenesis, biomarkers, diagnosis, and treatment strategies for major pediatric vasculitides including IgA vasculitis, Kawasaki Disease, ANCA-associated vasculitis, Takayasu arteritis, and Polyarteritis Nodosa. Novel insights from genetic, immunologic, and imaging studies have paved the way for early diagnosis and individualized therapeutic approaches. Future directions emphasize the role of artificial intelligence, precision medicine, and international collaborative trials to optimize long-term outcomes and quality of life in affected children.