Research Information System
EurAsian Journal of Oral and Maxillofacial Surgery, no.4, pp.111-119, 2024 (Peer-Reviewed Journal)
Objective: This observational retrospective study aims to compare the effects of alprazolam and hydroxyzine on cardiac autonomic activity and physiological parameters in dental anxiety.
Methods: This study included 90 participants, divided into three groups: alprazolam (n=30), hydroxyzine (n=30), and control (n=30). Each group consisted of 15 males and 15 females, with mean ages of 37.68 ± 4.32 years, 38.53 ± 3.98 years, and 37.38 ± 4.15 years, respectively. Alprazolam and hydroxyzine groups received 0.5 mg of their respective medications one hour before oral surgical procedures. Blood pressure, heart rate, and oxygen saturation were measured at: preoperatively, intraoperatively (at 30-minute intervals), and postoperatively. Uniform surgical protocols were followed across all groups, and data were analyzed using ANOVA.
Results: In the control group, there was a significant increase in systolic and diastolic blood pressure and heart rate from preoperative to intraoperative measurements and a significant decrease in postoperative measurements compared to intraoperative values. In the hydroxyzine group, intraoperative systolic blood pressure and heart rate decreased compared to preoperative values, while postoperative values showed no significant change compared to intraoperative values. Diastolic blood pressure did not significantly change over time. In the alprazolam group, all values decreased significantly over time. Also, the alprazolam group showed a statistically significant decrease in all values compared to the hydroxyzine group. Conclusion: Both medications are effective compared to a control group for cardiovascular values. These findings may indicate that alprazolam and hydroxyzine may be viable options for preventing anxiety, with alprazolam being the more potent medication.