Iridoid glycosides of <i>Leonurus persicus</i>

Tasdemir D., Scapozza L., Zerbe O., Linden A., Çalis I., Sticher O.

JOURNAL OF NATURAL PRODUCTS, sa.6, ss.811-816, 1999 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1021/np980376e
  • Dergi Adı: JOURNAL OF NATURAL PRODUCTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Sayfa Sayıları: ss.811-816
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Two new iridoid glucosides, 6-O-acetylajugol (1) and 7,8-epoxy-8-epi-loganic acid (2), together with five known iridoid glucosides, galiridoside (3), ajugoside (4), 10-deoxygeniposidic acid (5), 7-deoxy-8-epi-loganic acid (6), and 8-O-acetylharpagide (7), have been isolated from the aerial parts of Leonurus persicus. Leucosceptoside A (8), eugenyl beta-rutinoside (9), and kaempferol 3-O-glucoside (10) were also isolated. The structures of 1 and 2 were elucidated by extensive 1D- and BD-NMR spectroscopy and molecular modeling. The structure of 3 was confirmed by single-crystal X-ray diffraction. Antimicrobial activity of compounds (1-10) was also evaluated against a panel of Gram-positive and Gram-negative bacteria and two strains of fungi.