PARP inhibition prevents acetaminophen-induced liver injury and increases survival rate in rats

DONMEZ, Melahat; UYSAL, Bulent; POYRAZOGLU, Yavuz; ER ÖZTAŞ, YEŞİM; TURKER, Turker; KALDIRIM, Umit; KORKMAZ, Ahmet

doi:10.3906/sag-1308-48

PARP inhibition prevents acetaminophen-induced liver injury and increases survival rate in rats

DONMEZ M., UYSAL B., POYRAZOGLU Y., ER ÖZTAŞ Y., TURKER T., KALDIRIM U., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.45, sa.1, ss.18-26, 2015 (SCI-Expanded, Scopus, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 45 Sayı: 1
Basım Tarihi: 2015
Doi Numarası: 10.3906/sag-1308-48
Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.18-26
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Hacettepe Üniversitesi Adresli: Evet

Özet

Background/aim: Acetaminophen (APAP) overdose results in severe liver damage that may develop into acute liver failure. Recent studies have demonstrated that inhibition of poly(ADP-ribose) polymerase (PARP) decreases tissue necrosis and inflammation. We evaluated the efficacy of 3-aminobenzamide (3-AB), a PARP inhibitor, in a rodent model of APAP-induced hepatotoxicity.