PARP inhibition prevents acetaminophen-induced liver injury and increases survival rate in rats


DONMEZ M., UYSAL B., POYRAZOGLU Y., ER ÖZTAŞ Y., TURKER T., KALDIRIM U., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.45, no.1, pp.18-26, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.3906/sag-1308-48
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.18-26
  • Hacettepe University Affiliated: Yes

Abstract

Background/aim: Acetaminophen (APAP) overdose results in severe liver damage that may develop into acute liver failure. Recent studies have demonstrated that inhibition of poly(ADP-ribose) polymerase (PARP) decreases tissue necrosis and inflammation. We evaluated the efficacy of 3-aminobenzamide (3-AB), a PARP inhibitor, in a rodent model of APAP-induced hepatotoxicity.