PARP inhibition prevents acetaminophen-induced liver injury and increases survival rate in rats

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DONMEZ M., UYSAL B., POYRAZOGLU Y., ER ÖZTAŞ Y., TURKER T., KALDIRIM U., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.45, no.1, pp.18-26, 2015 (SCI-Expanded, Scopus, TRDizin)

• Publication Type: Article / Article
• Volume: 45 Issue: 1
• Publication Date: 2015
• Doi Number: 10.3906/sag-1308-48
• Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.18-26
• Open Archive Collection: AVESIS Open Access Collection
• Hacettepe University Affiliated: Yes

Abstract

Background/aim: Acetaminophen (APAP) overdose results in severe liver damage that may develop into acute liver failure. Recent studies have demonstrated that inhibition of poly(ADP-ribose) polymerase (PARP) decreases tissue necrosis and inflammation. We evaluated the efficacy of 3-aminobenzamide (3-AB), a PARP inhibitor, in a rodent model of APAP-induced hepatotoxicity.