PARP inhibition prevents acetaminophen-induced liver injury and increases survival rate in rats


DONMEZ M., UYSAL B., POYRAZOGLU Y., ER ÖZTAŞ Y. , TURKER T., KALDIRIM U., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.45, ss.18-26, 2015 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 45 Konu: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3906/sag-1308-48
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Sayfa Sayıları: ss.18-26

Özet

Background/aim: Acetaminophen (APAP) overdose results in severe liver damage that may develop into acute liver failure. Recent studies have demonstrated that inhibition of poly(ADP-ribose) polymerase (PARP) decreases tissue necrosis and inflammation. We evaluated the efficacy of 3-aminobenzamide (3-AB), a PARP inhibitor, in a rodent model of APAP-induced hepatotoxicity.