PARP inhibition prevents acetaminophen-induced liver injury and increases survival rate in rats

Creative Commons License

DONMEZ M., UYSAL B., POYRAZOGLU Y., ER ÖZTAŞ Y., TURKER T., KALDIRIM U., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.45, sa.1, ss.18-26, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3906/sag-1308-48
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.18-26
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background/aim: Acetaminophen (APAP) overdose results in severe liver damage that may develop into acute liver failure. Recent studies have demonstrated that inhibition of poly(ADP-ribose) polymerase (PARP) decreases tissue necrosis and inflammation. We evaluated the efficacy of 3-aminobenzamide (3-AB), a PARP inhibitor, in a rodent model of APAP-induced hepatotoxicity.