Importance of Prenatal Diagnosis in Patients with History of Chromosomal Abnormalities


TANAÇAN A., ÜNAL C., Yucesoy H. M. , FADILOĞLU E., BEKSAÇ M. S.

INTERNATIONAL JOURNAL OF HUMAN GENETICS, vol.19, no.3, pp.146-151, 2019 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.31901/24566330.2019/19.03.723
  • Journal Name: INTERNATIONAL JOURNAL OF HUMAN GENETICS
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.146-151

Abstract

The researchers retrospectively evaluated the data of patients who underwent invasive prenatal diagnostic tests with respect to the following risk factors: 1) history of chromosomal abnormality in the family (n=36), 2) history of chromosomal abnormality in a previous pregnancy (n=18), and 3) history of chromosomal abnormality in the parents (n=3) between 2000 and 2017. The diagnostic test results of patients with a history of chromosomal abnormality in the family and those with a history of a chromosomal abnormality in a previous pregnancy were compared. A total of 57 invasive procedures were evaluated. The aneuploidy rates were 41.7 percent and 16.7 percent for patients with a history of chromosomal abnormality in the family and patients with a history of chromosomal abnormality in a previous pregnancy respectively (p = 0.085). Invasive prenatal tests should be recommended to patients at high risk of chromosomal aneuploidy.