Importance of Prenatal Diagnosis in Patients with History of Chromosomal Abnormalities


TANAÇAN A. , ÜNAL C. , Yucesoy H. M. , FADILOĞLU E. , BEKSAÇ M. S.

INTERNATIONAL JOURNAL OF HUMAN GENETICS, cilt.19, ss.146-151, 2019 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 19 Konu: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.31901/24566330.2019/19.03.723
  • Dergi Adı: INTERNATIONAL JOURNAL OF HUMAN GENETICS
  • Sayfa Sayıları: ss.146-151

Özet

The researchers retrospectively evaluated the data of patients who underwent invasive prenatal diagnostic tests with respect to the following risk factors: 1) history of chromosomal abnormality in the family (n=36), 2) history of chromosomal abnormality in a previous pregnancy (n=18), and 3) history of chromosomal abnormality in the parents (n=3) between 2000 and 2017. The diagnostic test results of patients with a history of chromosomal abnormality in the family and those with a history of a chromosomal abnormality in a previous pregnancy were compared. A total of 57 invasive procedures were evaluated. The aneuploidy rates were 41.7 percent and 16.7 percent for patients with a history of chromosomal abnormality in the family and patients with a history of chromosomal abnormality in a previous pregnancy respectively (p = 0.085). Invasive prenatal tests should be recommended to patients at high risk of chromosomal aneuploidy.