Effects of N-acetyl cysteine, vitamin E and vitamin C on liver glutathione levels following amiodarone treatment in rats

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ÇETİN E., Erdem B., Unlu A., DURUKAN A. B., ONUR M. A.

KARDIOCHIRURGIA I TORAKOCHIRURGIA POLSKA-POLISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, vol.16, no.2, pp.88-92, 2019 (ESCI)

• Publication Type: Article / Article
• Volume: 16 Issue: 2
• Publication Date: 2019
• Doi Number: 10.5114/kitp.2019.86361
• Journal Name: KARDIOCHIRURGIA I TORAKOCHIRURGIA POLSKA-POLISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
• Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
• Page Numbers: pp.88-92
• Keywords: amiodarone, toxicity, N-acetyl cysteine, vitamin E, ascorbic acid, hepatotoxicity, rats, ATRIAL-FIBRILLATION, MITOCHONDRIAL DYSFUNCTION, OXIDATIVE STRESS, TOXICITY, CYTOTOXICITY, PREVENTION, MECHANISMS
• Hacettepe University Affiliated: Yes

Abstract

Introduction: Amiodarone, a pharmaceutical extensively used to suppress atrial and ventricular tachyarrhythmias, is also known to cause many side effects on many tissues. N-acetyl-cysteine (NAC), vitamin E and vitamin C are known as antioxidants for their ability to minimize oxidative stress. In the peer-reviewed literature, there is no study reporting on the protective effects of these antioxidant agents against its hepatotoxicity.