JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.20, no.5, pp.503-514, 2005 (SCI-Expanded)
The synthesis and antioxidant evaluation of some novel benzimidazole derivatives (10-24) are described. Antioxidant properties of the compounds were investigated employing various in vitro systems viz., microsomal NADPH-dependent inhibition of lipid peroxidation (LP), interaction of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and scavenging of superoxide anion radical. Compounds 12 and 13 showed very good antioxidant capacity and were 17-18 -fold more potent than BHT (IC50 2.3 X 10(-4)M) with 1.3 X 10(-5)M and 1.2 X 10(-5)M IC50 values, respectively, by interaction of the stable DPPH free radical.