Synthesis, antioxidant and radical scavenging activities of novel benzimidazoles


AYHAN-KILCIGIL G., KU C., COBAN T., CAN-EKE B., Ozbey S., ISCAN M.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.20, no.5, pp.503-514, 2005 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 5
  • Publication Date: 2005
  • Doi Number: 10.1080/14756360500287086
  • Journal Name: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.503-514

Abstract

The synthesis and antioxidant evaluation of some novel benzimidazole derivatives (10-24) are described. Antioxidant properties of the compounds were investigated employing various in vitro systems viz., microsomal NADPH-dependent inhibition of lipid peroxidation (LP), interaction of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and scavenging of superoxide anion radical. Compounds 12 and 13 showed very good antioxidant capacity and were 17-18 -fold more potent than BHT (IC50 2.3 X 10(-4)M) with 1.3 X 10(-5)M and 1.2 X 10(-5)M IC50 values, respectively, by interaction of the stable DPPH free radical.