Synthesis, antioxidant and radical scavenging activities of novel benzimidazoles

AYHAN-KILCIGIL, G; KU, C; COBAN, T; CAN-EKE, B; Ozbey, SÜHEYLA; ISCAN, M

doi:10.1080/14756360500287086

Synthesis, antioxidant and radical scavenging activities of novel benzimidazoles

Atıf İçin Kopyala

AYHAN-KILCIGIL G., KU C., COBAN T., CAN-EKE B., Ozbey S., ISCAN M.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.20, sa.5, ss.503-514, 2005 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 20 Sayı: 5
Basım Tarihi: 2005
Doi Numarası: 10.1080/14756360500287086
Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.503-514
Hacettepe Üniversitesi Adresli: Evet

Özet

The synthesis and antioxidant evaluation of some novel benzimidazole derivatives (10-24) are described. Antioxidant properties of the compounds were investigated employing various in vitro systems viz., microsomal NADPH-dependent inhibition of lipid peroxidation (LP), interaction of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and scavenging of superoxide anion radical. Compounds 12 and 13 showed very good antioxidant capacity and were 17-18 -fold more potent than BHT (IC50 2.3 X 10(-4)M) with 1.3 X 10(-5)M and 1.2 X 10(-5)M IC50 values, respectively, by interaction of the stable DPPH free radical.