Serum sCTLA-4 levels and clinical manifestations in ankylosing spondylitis patients


ÇETİNTEPE S. P. , ŞENTÜRK T., Sargin G., AYDIN N.

EUROPEAN JOURNAL OF RHEUMATOLOGY, vol.5, no.2, pp.115-117, 2018 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.5152/eurjrheum.2018.17114
  • Journal Name: EUROPEAN JOURNAL OF RHEUMATOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.115-117
  • Hacettepe University Affiliated: Yes

Abstract

Objective: T cell abnormal activation is thought to have a main role in the etiology of ankylosing spondylitis (AS). While cytotoxic T lymphocyte-associated molecule-4 (CTLA-4) is suppressing the immune system, in previous studies serum soluble CTLA-4 (sCTLA-4) was detected at high amounts in autoimmune disorders. We sought to evaluate the association between soluble CTLA-4 in serum and disease activity in AS patients.