BOSENTAN, A NON-SPECIFIC ENDOTHELIN ANTAGONIST, STIMULATES FRACTURE HEALING


Muratli H. H. , KORKUSUZ P. , KORKUSUZ P. , Bicimoglu A., Ercan Z. S.

BIOMEDICAL ENGINEERING-APPLICATIONS BASIS COMMUNICATIONS, cilt.19, ss.37-46, 2007 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 19 Konu: 1
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1142/s1016237207000045
  • Dergi Adı: BIOMEDICAL ENGINEERING-APPLICATIONS BASIS COMMUNICATIONS
  • Sayfa Sayıları: ss.37-46

Özet

It is assumed that bosentan, a non-selective ET-1 receptor antagonist, will enhance fracture healing. The aim of this prospective randomized controlled study was to investigate the effects of transcutaneous bosentan administration into diaphyseal bone fractures using radiology, histology, prostaglandin E-2 (PGE(2)) and leukotrien C-4 (LTC4) activity measurements.