Bisphenol A and phthalate levels in adolescents with polycystic ovary syndrome

Akgül S., Sur Ü., Düzçeker Y., Balcı A., Kızılkan M., Kanbur N., ...More

GYNECOLOGICAL ENDOCRINOLOGY, vol.35, no.12, pp.1084-1087, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 12
  • Publication Date: 2019
  • Doi Number: 10.1080/09513590.2019.1630608
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1084-1087
  • Keywords: Adolescents, bisphenol A, endocrine disruptor, phthalates, polycystic ovary syndrome, ENDOCRINE-DISRUPTING CHEMICALS, SYNDROME PCOS, EXPOSURE, CONSENSUS, PATTERN
  • Hacettepe University Affiliated: Yes


Endocrine disruptors have been proposed in the etiology of polycystic ovary syndrome (PCOS) as they have the potency to interfere with hormone-sensitivity systems. The aim of this study was to evaluate the levels of bisphenol A (BPA) and phtalates in adolescents with PCOS. Sixty-two girls with PCOS and 33 controls, age 12-18 years were enrolled in the study. The diagnosis of PCOS was made using modified Rotterdam criteria. Urinary BPA levels were measured using high-performance liquid chromatography. Di-(2-ethylhexyl)-phthalate (DEHP), the most commonly used phthalate and mono-(2-ethylhexyl)-phthalate (MEHP), its main metabolite were measured by using high-performance liquid chromatography. Adolescents with PCOS had markedly increased BPA levels (15.89 mu g/g creatine +/- 1.16) when compared with the control group (7.30 mu g/g creatine +/- 1.38) (p = .016). In adolescents with PCOS, BPA was significantly correlated with polycystic morphology on ultrasound but not with obesity androgen levels, or other metabolic parameters. Patients with PCOS (DEHP: 0.40 ppm +/- 0.24, MEHP: 0.13 ppm +/- 0.23) and controls (DEHP: 0.49 ppm +/- 0.27, MEHP: 0.14 ppm +/- 0.3) had similar serum phtalate concentrations (p = .7 and p = .3, respectively). Exposure to specific endocrine disruptors such as BPA could modify neuroendocrine, reproductive, and metabolic regulation favoring PCOS development in adolescents.