Akademik Veri Yönetim Sistemi
Hacettepe University Journal of the Faculty of Pharmacy, cilt.44, sa.1, ss.75-91, 2024 (Scopus)
Despite the development of therapeutics and treatment approaches for cancer treatment, the disease remains one of the leading causes of death worldwide. Due to limitations such as lack of specificity, cytotoxicity, and multidrug resistance, the desired level of success has not yet been achieved with cancer treatments such as chemotherapy, radiation therapy, and immunotherapy. Therefore, it is of great importance to develop targeted treatments to provide effective treatment by reducing side effects. However, the cancer microenvironment, with its vascularization and hypoxic regions, has many physiological obstacles to targeting. Research from the 1800s to the present has shown that bacteria are selective for cancer tissue by overcoming these physiological barriers. With the discovery that bacteria naturally can target and accumulate in tumor tissues, researchers have focused on bacteria mediated drug delivery systems. It has been reported that bacteria are superior to conventional drug carrier systems with their mobility, immune response, and easy modification properties. In this review, the most current developments in the literature on bacteria mediated drug delivery systems for cancer treatment are evaluated.