Diğer, ss.144-151, 2016
The electrochemical reduction and oxidation behaviour of Cefuroxime Axetil was investigated by square wave
voltammetry in different supporting electrolytes. Cefuroxime Axetil has both reducible and oxidacible groups
in its structure. The optimum conditions were obtained in 0.1 M phosphate borate buffer pH 7.0 for
electroreduction at hanging mercury drop electrode. A well-defined peak was observed at −1.06 V vs.
Ag/AgCl/4.6 M KCl. The optimumconditionswere obtained in Britton-Robinson buffer pH 2.0 for electrooxidation
at modified glassy carbon electrode. A well-defined peak was observed at 1.30 V vs. Ag/AgCl/4.6 M KCl. Current
type, reversibility of electrode reactions and the number of electrons transferred was investigated by using cyclic
voltammetry, chronoamperometry and chronocoulometry. Besides calculation of diffusion coefficients and the
rate constants of electron transfer, the reduction and oxidation mechanisms were also proposed.