Investigation of electrochemical behaviour of cefuroxime axetil using hanging mercury drop electrode and graphene oxide modified glassy carbon electrode

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Erdoğan Kablan S., Özaltın N.

Other, pp.144-151, 2016

  • Publication Type: Other Publication / Other
  • Publication Date: 2016
  • Page Numbers: pp.144-151
  • Hacettepe University Affiliated: Yes


The electrochemical reduction and oxidation behaviour of Cefuroxime Axetil was investigated by square wave

voltammetry in different supporting electrolytes. Cefuroxime Axetil has both reducible and oxidacible groups

in its structure. The optimum conditions were obtained in 0.1 M phosphate borate buffer pH 7.0 for

electroreduction at hanging mercury drop electrode. A well-defined peak was observed at −1.06 V vs.

Ag/AgCl/4.6 M KCl. The optimumconditionswere obtained in Britton-Robinson buffer pH 2.0 for electrooxidation

at modified glassy carbon electrode. A well-defined peak was observed at 1.30 V vs. Ag/AgCl/4.6 M KCl. Current

type, reversibility of electrode reactions and the number of electrons transferred was investigated by using cyclic

voltammetry, chronoamperometry and chronocoulometry. Besides calculation of diffusion coefficients and the

rate constants of electron transfer, the reduction and oxidation mechanisms were also proposed.