SYNTHESIS OF SOME 1,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AND THEIR CALCIUM ANTAGONISTIC ACTIVITY

SAFAK C., ERDEMLI I., SUNAL R.

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, no.10, pp.1052-1055, 1993 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 1993
  • Doi Number: 10.1016/s0014-827x(00)00086-0
  • Journal Name: ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, International Pharmaceutical Abstracts
  • Page Numbers: pp.1052-1055
  • Hacettepe University Affiliated: Yes

Abstract

Twenty-seven new 2-methyl-3-acetyl-4-aryl-5-oxo-1,4, 5,6,7,8-hexahydroquinoline derivatives have been prepared Their structures were confirmed by UV IR, H-1 NMR and elementary analysis. The calcium antagonistic activity of these compounds was tested in K+-depolarized taenia coli precontracted with 1 mmol/l Ca+2.