SYNTHESIS OF SOME 1,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AND THEIR CALCIUM ANTAGONISTIC ACTIVITY


SAFAK C. , ERDEMLI I. , SUNAL R.

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, ss.1052-1055, 1993 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Basım Tarihi: 1993
  • Doi Numarası: 10.1016/s0014-827x(00)00086-0
  • Dergi Adı: ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH
  • Sayfa Sayıları: ss.1052-1055

Özet

Twenty-seven new 2-methyl-3-acetyl-4-aryl-5-oxo-1,4, 5,6,7,8-hexahydroquinoline derivatives have been prepared Their structures were confirmed by UV IR, H-1 NMR and elementary analysis. The calcium antagonistic activity of these compounds was tested in K+-depolarized taenia coli precontracted with 1 mmol/l Ca+2.