Identification of the difference in extracellular matrix and adhesion molecules of cultured human gingival fibroblasts versus juvenile hyaline fibromatosis gingival fibroblasts using cDNA microarray analysis

Hakki S., Balci B., Hakki E., Yilmaz E., Nohutcu R.

JOURNAL OF PERIODONTOLOGY, cilt.76, sa.12, ss.2244-2253, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 76 Konu: 12
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1902/jop.2005.76.12.2244
  • Sayfa Sayıları: ss.2244-2253


Background: A difference from the normal range in collagen profile and perivascular hyaline deposition in the dermis and gingiva has been demonstrated histopathologically in juvenile hyaline fibromatosis (JHF), which is an autosomal recessive disease. The aim of this study was to understand the mechanism of gingival overgrowth in JHF, and to observe differences in the expression of genes regulating extracellular matrix organization.