Identification of the difference in extracellular matrix and adhesion molecules of cultured human gingival fibroblasts versus juvenile hyaline fibromatosis gingival fibroblasts using cDNA microarray analysis.

Hakki S., Balci B., Hakki E., Yilmaz E., Nohutcu R.

Journal of periodontology, vol.76, no.12, pp.2244-53, 2005 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 76 Issue: 12
  • Publication Date: 2005
  • Doi Number: 10.1902/jop.2005.76.12.2244
  • Journal Name: Journal of periodontology
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.2244-53


Background: A difference from the normal range in collagen profile and perivascular hyaline deposition in the dermis and gingiva has been demonstrated histopathologically in juvenile hyaline fibromatosis (JHF), which is an autosomal recessive disease. The aim of this study was to understand the mechanism of gingival overgrowth in JHF, and to observe differences in the expression of genes regulating extracellular matrix organization.