Familial Hypercholesterolemia: Global Burden and Approaches

Tokgozoglu L., KAYIKÇIOĞLU L. M.

CURRENT CARDIOLOGY REPORTS, vol.23, no.10, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 23 Issue: 10
  • Publication Date: 2021
  • Doi Number: 10.1007/s11886-021-01565-5
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE
  • Keywords: Familial hypercholesterolemia, Guidelines, Low-density lipoprotein cholesterol, Lipoprotein(a), LDL-APHERESIS, CARDIOVASCULAR EVENTS, ATHEROSCLEROSIS, CHOLESTEROL, EVOLOCUMAB, CLINICIAN, EFFICACY, RISK, INHIBITION, ALIROCUMAB
  • Hacettepe University Affiliated: Yes


Purpose of Review Familial hypercholesterolemia (FH) is the most common genetic metabolic disorder characterized by markedly elevated LDL-C levels from birth leading to atherosclerotic cardiovascular disease (ASCVD) and premature deaths. The purpose of this review is to share the current knowledge in the diagnosis, risk estimation, and management of patients with FH in the light of recent evidence and guideline recommendations.