Dosage delivery of chiral ruthenium catalysts using non-ionic surfactants for asymmetric transfer hydrogenation reactions in aqueous media

ÖZTÜRK B. Ö., Aklan M., KARABULUT ŞEHİTOĞLU S.

REACTION CHEMISTRY & ENGINEERING, cilt.8, sa.2, ss.424-431, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1039/d2re00335j
  • Dergi Adı: REACTION CHEMISTRY & ENGINEERING
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, Compendex, INSPEC
  • Sayfa Sayıları: ss.424-431
  • Hacettepe Üniversitesi Adresli: Evet

Özet

In this study, non-ionic surfactants, namely Synperonic (R) F108 and Tween (R) F108, were used as media to dissolve [RuCl(p-cymene)(R,R)-Ts-DPEN] for the dosage delivery and recycling of chiral ruthenium catalysts in asymmetric transfer hydrogenation reactions of ketones in water. The non-ionic surfactant-based catalytic systems bearing ruthenium catalysts in microgram scale can be used directly to conduct transfer hydrogenation reactions in nano-sized micelle structures (60-90 nm) in water under an air atmosphere. The micellar catalyst in the aqueous phase can be recycled from the reaction mixture and can be used up to 8 times in asymmetric transfer hydrogenation reactions of acetophenone.