Dosage delivery of chiral ruthenium catalysts using non-ionic surfactants for asymmetric transfer hydrogenation reactions in aqueous media

ÖZTÜRK B. Ö., Aklan M., KARABULUT ŞEHİTOĞLU S.

REACTION CHEMISTRY & ENGINEERING, vol.8, no.2, pp.424-431, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.1039/d2re00335j
  • Journal Name: REACTION CHEMISTRY & ENGINEERING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, Compendex, INSPEC
  • Page Numbers: pp.424-431
  • Hacettepe University Affiliated: Yes

Abstract

In this study, non-ionic surfactants, namely Synperonic (R) F108 and Tween (R) F108, were used as media to dissolve [RuCl(p-cymene)(R,R)-Ts-DPEN] for the dosage delivery and recycling of chiral ruthenium catalysts in asymmetric transfer hydrogenation reactions of ketones in water. The non-ionic surfactant-based catalytic systems bearing ruthenium catalysts in microgram scale can be used directly to conduct transfer hydrogenation reactions in nano-sized micelle structures (60-90 nm) in water under an air atmosphere. The micellar catalyst in the aqueous phase can be recycled from the reaction mixture and can be used up to 8 times in asymmetric transfer hydrogenation reactions of acetophenone.