The aim of the present case report was to compare the soft tissue measurements, and volumetric differences on the face of the patient whose complete dentures were fabricated either with conventional or neutral zone impression techniques. Two different complete dentures were fabricated according to conventional and neutral zone impression techniques. The measurement of soft tissue changes was evaluated on lateral cephalograms; conventional technique (L1), neutral zone technique (L2) and with no dentures (L3). Three images (I) were taken on the same day respectively with dentures completed by conventional technique (I1), dentures completed by neutral zone technique (I2), and with no dentures (I3). The superimposition of the images was evaluated. The cephalometric soft tissue measurements of the present case showed that upper and lower lips were positioned anteriorly in both conventional (L1) and neutral zone techniques (L2) on the sagittal plane. These results could be attributed to the fact that the placement of the prosthesis in the mouth helps direct lip position with big linear measurements. Volumetric difference between conventional (I1) and no denture (I3) images was more pronounced compared to neutral zone (I2) superposition with no denture (I3).