Emulation of the control cohort of a randomized controlled trial in pediatric kidney transplantation with Real-World Data from the CERTAIN Registry

Patry, Christian; Sauer, Lukas; Sander, Anja; Krupka, Kai; Fichtner, Alexander; Brezinski, Jolanda; Geissbuehler, Yvonne; Aubrun, Elodie; Grinienko, Anna; Dello Strologo, Luca; Haffner, Dieter; Oh, Jun; Grenda, Ryszard; Pape, Lars; TOPALOĞLU, REZAN; Weber, Lutz; Bouts, Antonia; Kim, Jon; Prytula, Agnieszka; Koenig, Jens; Shenoy, Mohan; Hoecker, Britta; Toenshoff, Burkhard

doi:10.1007/s00467-022-05777-x

Emulation of the control cohort of a randomized controlled trial in pediatric kidney transplantation with Real-World Data from the CERTAIN Registry

Patry C., Sauer L. D., Sander A., Krupka K., Fichtner A., Brezinski J., ...More

PEDIATRIC NEPHROLOGY, vol.38, no.5, pp.1621-1632, 2023 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 38 Issue: 5
Publication Date: 2023
Doi Number: 10.1007/s00467-022-05777-x
Journal Name: PEDIATRIC NEPHROLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
Page Numbers: pp.1621-1632
Keywords: Real-World Data, Emulated cohorts, Clinical trial design, Pediatric kidney transplantation, WEB-BASED REGISTRY, RENAL-TRANSPLANTATION, CHILDREN, BASILIXIMAB, ADOLESCENTS
Open Archive Collection: AVESIS Open Access Collection
Hacettepe University Affiliated: Yes

Abstract

Background Randomized controlled trials in pediatric kidney transplantation are hampered by low incidence and prevalence of kidney failure in children. Real-World Data from patient registries could facilitate the conduct of clinical trials by substituting a control cohort. However, the emulation of a control cohort by registry data in pediatric kidney transplantation has not been investigated so far.