Emulation of the control cohort of a randomized controlled trial in pediatric kidney transplantation with Real-World Data from the CERTAIN Registry

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Patry C., Sauer L. D., Sander A., Krupka K., Fichtner A., Brezinski J., ...More

PEDIATRIC NEPHROLOGY, vol.38, no.5, pp.1621-1632, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 5
  • Publication Date: 2023
  • Doi Number: 10.1007/s00467-022-05777-x
  • Journal Name: PEDIATRIC NEPHROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1621-1632
  • Keywords: Real-World Data, Emulated cohorts, Clinical trial design, Pediatric kidney transplantation, WEB-BASED REGISTRY, RENAL-TRANSPLANTATION, CHILDREN, BASILIXIMAB, ADOLESCENTS
  • Hacettepe University Affiliated: Yes

Abstract

Background Randomized controlled trials in pediatric kidney transplantation are hampered by low incidence and prevalence of kidney failure in children. Real-World Data from patient registries could facilitate the conduct of clinical trials by substituting a control cohort. However, the emulation of a control cohort by registry data in pediatric kidney transplantation has not been investigated so far.