Magnetically Responsive, Sorafenib Loaded Alginate Microspheres for Hepatocellular Carcinoma Treatment

Alpdemir Ş., Vural T., Kara G., Bayram C., Haberal E., Denkbaş E. B.

Iet Nanobiotechnology, no.8, pp.1-8, 2020 (SCI-Expanded)

  • Publication Type: Article / Article
  • Publication Date: 2020
  • Journal Name: Iet Nanobiotechnology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Applied Science & Technology Source, BIOSIS, Biotechnology Research Abstracts, Business Source Elite, Business Source Premier, Communication Abstracts, Compendex, Computer & Applied Sciences, EMBASE, INSPEC, MEDLINE, Metadex, Civil Engineering Abstracts
  • Page Numbers: pp.1-8
  • Hacettepe University Affiliated: Yes


The present study aimed to develop sorafenib loaded magnetic microspheres for the treatment of hepatocellular carcinoma. To achieve this goal, superparamagnetic iron oxide nanoparticles were synthesized and encapsulated in alginate microspheres with together an antineoplastic agent, sorafenib. In the study, firstly SPIONs were synthesized and characterized by dynamic light scattering, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. Then, alginate-SPIONs microspheres were developed, and further characterized by electron spin resonance spectrometer and vibrating sample magnetometer. Besides the magnetic properties of SPIONs, alginate microspheres with SPIONs were also found to have magnetic properties.  The potential use of microspheres in hyperthermia treatment was then investigated and an increase of about 4°C in the environment was found out. Drug release studies and cytotoxicity tests were performed after sorafenib was encapsulated into the magnetic microspheres. According to release studies, sorafenib has been released from microspheres for eight hours. Cytotoxicity tests showed that alginate-SPION-sorafenib microspheres were highly effective against cancerous cells and promising for cancer therapy.