Iet Nanobiotechnology, sa.8, ss.1-8, 2020 (SCI-Expanded)
The
present study aimed to develop sorafenib loaded magnetic microspheres for the treatment
of hepatocellular carcinoma. To achieve this goal, superparamagnetic iron oxide
nanoparticles were synthesized and encapsulated in alginate microspheres with
together an antineoplastic agent, sorafenib. In the study, firstly SPIONs were
synthesized and characterized by dynamic light scattering, scanning electron
microscopy, and energy-dispersive X-ray spectroscopy. Then, alginate-SPIONs
microspheres were developed, and further characterized by electron spin
resonance spectrometer and vibrating sample magnetometer. Besides the magnetic
properties of SPIONs, alginate microspheres with SPIONs were also found to have
magnetic properties. The potential use of
microspheres in hyperthermia treatment was then investigated and an increase of
about 4°C
in the environment was found out. Drug release studies and cytotoxicity tests
were performed after sorafenib was encapsulated into the magnetic microspheres.
According to release studies, sorafenib has been released from microspheres for
eight hours. Cytotoxicity tests showed that alginate-SPION-sorafenib
microspheres were highly effective against cancerous cells and promising for
cancer therapy.