ULUSAL TRAVMA VE ACIL CERRAHI DERGISI, vol.29, no.5, pp.566-573, 2023 (SCI-Expanded)
BACKGROUND: Acute appendicitis (AA) is one of the most important causes of acute abdominal pain in children who are admitted
to the pediatric emergency department. This study aims to determine the usefulness of the systemic immune-inflammation index (SII)
in predicting complicated appendicitis (CA) in pediatric patients.
METHODS: The patients who underwent surgery with the diagnosis of AA were evaluated retrospectively. AA and control groups
were formed. AA was divided into noncomplicated and CA groups. C-reactive protein (CRP), white blood cell (WBC) count, absolute
neutrophil count (ANC), absolute lymphocyte count, neutrophil/lymphocyte ratio (NLR), platelet (PLT)/lymphocyte ratio (PLR), and
SII values were recorded. The SII was calculated with the formula of PLT count × neutrophil/lymphocyte. The efficacy of biomarkers
in predicting CA was compared.
RESULTS: Our study included 1072 AA and 541 control patients. There were 74.3% of patients in the non-CA (NCA) group and
25.7% in the CA group. CRP, WBC count, ANC, NLR, PLR when AA and control group, complicated and NCA groups are compared
in terms of laboratory parameters and SII level AA and it was higher in the CA group. While the SII value was 2164.91±1831.24 in the
patients with NCA and 3132.59±2658.73 in those with CA (P<0.001). When the cut-off values were determined according to the area
under the curve, CRP and SII were found to be the best biomarkers in predicting CA.
CONCLUSION: Inflammation markers together with clinical evaluation may be useful in distinguishing noncomplicated and complicated AA. However, these parameters alone are not sufficient to predict CA. CRP and SII are the best predictors of CA in pediatric
patients.