Increased potassium excretion in children with monosymptomatic nocturnal enuresis: could it be related to Kir 4.1-KCNJ10 gene polymorphism?

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Balat A., PARLAK M., OĞUZKAN BALCI S., Gogebakan B., BÜYÜKÇELİK M., Col N., ...More

TURKISH JOURNAL OF PEDIATRICS, vol.62, no.2, pp.208-214, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.24953/turkjped.2020.02.006
  • Journal Name: TURKISH JOURNAL OF PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.208-214
  • Hacettepe University Affiliated: Yes

Abstract

Background and objectives. There are controversial results in the literature regarding urinary electrolytes, especially potassium, in enuretic children. KCNJ10 channel protein, a member of the Kir 4.1 family is expressed in renal distal tubules and has an important function in renal ion transport. We investigated whether KCNJ10 gene polymorphisms are associated with clinical and laboratory findings of a group of Turkish children with monosymptomatic primary nocturnal enuresis (MNE).