Racemic ethyl 4-(2-fluorophenyl)-2,6,6-trimethyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylate

Linden A., Safak C., Simsek R.

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, vol.54, pp.879-882, 1998 (SCI-Expanded) identifier identifier


The title compound, C21H24FNO3, has potential calcium modulatory properties. The 1,4-dihydropyridine ring has a shallow boat conformation with the 2-fluorophenyl substituent in an axial synperiplanar orientation. The quinoline ring has a half-chair conformation. Steric interactions between the adjacent methyl and erhoxycarbonyl substituents cause local bond-angle distortions. The molecules are linked into chains by intermolecular N-H ... O hydrogen bonds.