Racemic ethyl 4-(2-fluorophenyl)-2,6,6-trimethyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylate


Linden A. , Safak C., Simsek R.

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, vol.54, pp.879-882, 1998 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 54
  • Publication Date: 1998
  • Doi Number: 10.1107/s0108270198000195
  • Title of Journal : ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS
  • Page Numbers: pp.879-882

Abstract

The title compound, C21H24FNO3, has potential calcium modulatory properties. The 1,4-dihydropyridine ring has a shallow boat conformation with the 2-fluorophenyl substituent in an axial synperiplanar orientation. The quinoline ring has a half-chair conformation. Steric interactions between the adjacent methyl and erhoxycarbonyl substituents cause local bond-angle distortions. The molecules are linked into chains by intermolecular N-H ... O hydrogen bonds.