Best practice recommendations for the diagnosis and management of hypoparathyroidism

Khan, Aliya; Ali, Dalal; Bilezikian, John; Bjornsdottir, Sigridur; Collins, Michael; Cusano, Natalie; Ebeling, Peter; Fuleihan, Ghada; Fukumoto, Seiji; Giustina, Andrea; Kaiser, Stephanie; Koch, Christian; Khan, Tayyab; Keating, Patty; Liu, Jian-Min; Mantzoros, Christos; Mannstadt, Michael; Mithal, Ambrish; Perrier, Nancy; Rayes, Michele; Rizzoli, Rene; Rhee, Yumie; Rubin, Mishaela; Roszko, Kelly; Shrayyef, Muhammad; Shoback, Dolores; Sikjaer, Tanja; Siggelkow, Heide; Sfeir, Jad; Thakker, Rajesh; Van Uum, Stan; Winer, Karen; Yavuz, Dilek; YILDIZ, OKAN; Abualrob, Hajar; Brandi, Maria

doi:10.1016/j.metabol.2025.156335

Best practice recommendations for the diagnosis and management of hypoparathyroidism

Khan A. A., Ali D. S., Bilezikian J. P., Bjornsdottir S., Collins M. T., Cusano N. E., ...More

METABOLISM-CLINICAL AND EXPERIMENTAL, vol.171, 2025 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 171
Publication Date: 2025
Doi Number: 10.1016/j.metabol.2025.156335
Journal Name: METABOLISM-CLINICAL AND EXPERIMENTAL
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Artic & Antarctic Regions, BIOSIS, Chemical Abstracts Core, EMBASE
Hacettepe University Affiliated: Yes

Abstract

Background: Hypoparathyroidism (HypoPT) is characterized by low serum calcium due to insufficient parathyroid hormone (PTH). This manuscript builds upon the 2022 international HypoPT guidelines and three systematic reviews, which have been further informed by updated narrative reviews and expert consensus. This paper presents current best practice consensus recommendations for the diagnosis and management of HypoPT. Methods: An International Panel of Experts updated the previous systematic reviews (SR's), conducted narrative reviews, developed, and subsequently approved these best practice recommendations at the Parathyroid Summit, held as a pre-Endocrine Society meeting in May 2024 (Boston, USA). Results: Diagnostic criteria for chronic HypoPT require hypocalcemia with inappropriately normal or low PTH levels. Conventional therapy is recommended as first line therapy and includes calcium supplementation, active vitamin D, correction of vitamin D inadequacy and correction of abnormalities in serum magnesium. Monitoring Conclusion: These best practice recommendations provide a framework for HypoPT diagnosis and management, molecule palopegteriparatide based on recent clinical trial data and expert consensus.