The Relationship Between Polypharmacy and Geropsychiatric Assessment Scales in Geriatric Outpatients

Öztürk Y., Cömertoğlu E. O., HAFIZOĞLU M., KAHYAOĞLU Z., Çavuşoğlu Ç., BALCI C., ...More

European Journal of Geriatrics and Gerontology, vol.5, no.3, pp.225-230, 2023 (Scopus) identifier


Objective: The aim of the study was to investigate the association between geropsychiatric assessment scales and polypharmacy. Materials and Methods: A cross-sectional study was conducted that included patients ≥65 years, who applied to geriatric outpatients in a university hospital. Functionality was assessed by instrumental activities of daily living (IADL) and activities of daily living (ADL). The clinical frailty scale (CFS) was used for frailty screening. Multidimensional scale of perceived social support (MSPSS), mini-nutritional assessment-short form (MNA-SF), quality of life scale in older people (CASP-19), mini-mental state examination, loneliness scale for elderly, generalized anxiety disorder-7, geriatric depression scale (GDS), templer death anxiety scale, and cumulative illness rating scale for geriatrics (CIRS-G) were performed. Polypharmacy was defined as taking five or more medications. Results: The study included 136 patients with a median (interlique range) age of 72.2 (68.1-76.3). The prevalence of polypharmacy was 52.2%. Age, IADL, GDS, CFS, MSPSS, CASP-19, and CIRS-G scores significantly differed between the polypharmacy and non-polypharmacy groups (p<0.05). There were inverse correlations between the number of medications and ADL, IADL, MNA-SF, MSPSS, and CASP-19. GDS had a weak and positive correlation (p<0.001, r=0.322) whereas, CFS (p<0.001, r=0.463) and CIRS-G (p<0.001, r=0.530) had moderate and positive correlations. In multivariable analysis, age [odds ratio (OR), 1.087; 95% confidence interval (CI), 1.005-1.176], CFS (OR, 1.602; 95% CI, 1.048-2.448), and CIRS-G (OR, 1.273; 95% CI, 1.090-1.486) were independent variables. Conclusion: Age, CIRS-G, and frailty score by using CFS are independent variables of polypharmacy. The relationship between polypharmacy and functional dependency, depression, social support, and life quality should be supported by future large and comprehensive studies.