The sensitivity of quality-of-life scale WHOQOL-100 to psychopathological measures in schizophrenia

Orsel S., Akdemir A., DAĞ İ.

COMPREHENSIVE PSYCHIATRY, vol.45, no.1, pp.57-61, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 1
  • Publication Date: 2004
  • Doi Number: 10.1016/j.comppsych.2003.09.006
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.57-61
  • Hacettepe University Affiliated: Yes


We aimed to investigate the reliability and the clinical sensitivity of the World Health Organization Quality of Life (WHOQOL-100) scale for patients diagnosed with schizophrenia because of its multilingual, multidimensional, and cross-cultural properties. Fifty-four stabilized outpatients with schizophrenia and 49 age-, sex-, and occupation-matched healthy control subjects were recruited. The scale showed high internal consistency (Cronbach alpha = 0.94). While there was no correlation between total scores of psychopathology measures (Brief Psychiatric Rating Scale [BPRS], Scale for the assessment of Negative Symptoms [SANS], Scale for the Assessment of Positive Symptoms [SAPS], and Clinical Global Impression [CGI]), significant negative correlations were obtained especially between subscales of the BPRS, SANS, SAPS, and QOL domains. Stepwise multiple regression analysis also revealed that the BPRS anxiety/depression and SANS anhedonia subcales were the predictor variables in five of six QOL domains in the schizophrenia group. The better quality-of-life scores of the mild group on physical and psychological domains indicate that the WHOQOL-100 could be used as an outcome measure in clinical studies. Thus, the WHOQOL-100 scale is a reliable, subjective quality-of-life scale for patients diagnosed with schizophrenia. The clinical sensitivity should also be assessed in large follow-up studies. (C) 2004 Elsevier Inc. All rights reserved.