Neuroprotective effects of thymoquinone against spinal cord ischemia-reperfusion injury by attenuation of inflammation, oxidative stress, and apoptosis

Gokce E. C. , Kahveci R., Gokce A., Cemil B., Aksoy N., SARGON M. F. , ...Daha Fazla

JOURNAL OF NEUROSURGERY-SPINE, cilt.24, sa.6, ss.949-959, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Konu: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3171/2015.10.spine15612
  • Sayfa Sayıları: ss.949-959


OBJECTIVE lschemia-reperfusion (I/R) injury of the spinal cord following thoracoabdominal aortic surgery remains the most devastating complication, with a life-changing impact on the patient. Thymoquinone (TQ), the main constituent of the volatile oil from Nigella sativa seeds, is reported to possess strong antioxidant, antiinflammatory, and antiapoptotic properties. This study investigated the effects of TQ administration following I/R injury to the spinal cord.